Here are the setting I use, from top to bottom:
General
UNcheck memorize user interface options
UNcheck autoplay handler (I have autoplay turned off in windows)
UNcheck on-the-fly decrypter test (I know what I have running)
UNcheck check for new verion automatically*
UNcheck Create files in subfolders of output directory
Customize UI
UNcheck both boxes
A/V Codec
varies with content and your video card (set to all software and disable Lightning Recoding for crash problems*)
Preview
UNcheck both boxes under Playback*
DirectShow decoder, DXVA depends on your video card (I have it disabled)
Filters: DVDFab video and audio
Internal decoder for crash problems*
Sound
your choice
Network
varies with your network connection, I have it set for Direct Connection
Diagnosis
enable all logs, check Run Report program
DVD/Blu-ray->
Read
set mode to SPTI (unless you have Win98 or other odd/outdated OS)
Error control: select Ask Retry/Ignore/Abort
Cache Control: Enable, disable it if you get read errors or crashes or have limited system resources*
Blu-ray: set to Internal
UNcheck Do not eject Source when finished copying
Write (varies with burn engine)
Burning engine: ImgBurn
DVD
Write speed 8X (varies with media and burner)
DVD-5 size: 4464 MB (only with Verbatim or TY media, 4300 otherwise)
DVD-9 size: 8152 MB (Verbatim only, otherwise 8000)
SAO Write type
Blu-ray
Write speed: (varies with media and burner)
BD-25 size: 23700
BD-50 size: 43700
UNcheck all boxes except Set booktype to DVD-ROM if your drive supports it and you use +R media
Protection->
DVD
Check all boxes EXCEPT UNcheck Remove layer break if using ImgBurn
Blu-ray
Check all boxes
PathPlayer
Select Always Enable
set Scan cells (top) slider to 480 seconds or higher
set VOBU slider to 10 or lower
Note: these are what I call "deep scan" settings and will take longer; use the defaults (300/30) if it's too slow for you.
Check the Check for multiple sets of BOVs box
Streams
will vary with your location and preferences
I have it set for English audio, Dolby Digital, select first track from multiples; subpicture set for preselect English, and Do not preselect any track if there is no English
DVD Copy
your preferences
mine are set for DVD-9 and DVD Folder, dvdid.xml box unchecked.
Split and Customize set for Black screen and Disc 1.
Blu-ray Copy
Default size BD50
UNcheck full scan and HD Audio boxes
BD9/BD5 button set for software player friendly (lower button)
Encoding set for fast speed, Normal Quality
DVD/Blu-ray Ripper->
Convert
Check Enable Turbo CPU (varies with your CPU)
Memory selector to Auto (varies with your resources)
1CD= 700 MB
Check Crop Automatically
Default framerate set to specified in profile
Default Audio set to specified in profile
Audio downmix set to Stereo (depends on your player)
Output
your preference, I have it set to .