Jeppa,
I had no problems with the 2D version of Valerian, made with DVDFab x64 v10.0.7.6 and played through DVDFab Virtual Drive on !PowerDVD 17, also Fab Player 5 and VLC. Very smooth playback,no dropped frames. Please attach the DVDFab internal log from one of these that do not play 2D smoothly. Instructions for this are linked in my sig. I used CUDA to compress the disc, you might try the Software setting in AV Codec, although either should work.