It depends; not if you are re-installing on the same PC environment. If the only change will be to uninstall and re-install DVDFab it should work perfectly using the un-installer supplied with DVDFab. But if you are wiping the HDD and/or reinstalling the OS (or using an aggressive uninstaller (e.g. Revo)), you should de-authorize it first.
Post things like this in the General Questions forum next time. I will move it there so that others with the same question may find it easily in the future.
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